Article
The C. elegans heterochronic gene lin-46 affects developmental timing at two larval stages and encodes a relative of the scaffolding protein gephyrin.
Development (Cambridge, England) - 1 May 2004
Pepper Anita S-R, McCane Jill E, Kemper Kevin, Yeung Denise Au, Lee Rosalind C, Ambros Victor, Moss Eric G
Abstract excerpt
The succession of developmental events in the C. elegans larva is governed by the heterochronic genes. When mutated, these genes cause either precocious or retarded developmental phenotypes, in which stage-specific patterns of cell division and differentiation are either skipped or reiterated, respectively. We identified a new heterochronic gene, lin-46, from mutations that suppress the precocious phenotypes...
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