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Article

LIN-42, the Caenorhabditis elegans PERIOD homolog, negatively regulates microRNA transcription.

PLoS genetics - 1 Jul 2014

Perales Roberto, King Dana M, Aguirre-Chen Cristina, Hammell Christopher M

Abstract excerpt

During C. elegans development, microRNAs (miRNAs) function as molecular switches that define temporal gene expression and cell lineage patterns in a dosage-dependent manner. It is critical, therefore, that the expression of miRNAs be tightly regulated so that target mRNA expression is properly controlled. The molecular mechanisms that function to optimize or control miRNA levels during development are unknown....

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Identifiers

PMID: 25032706
DOI: 10.1371/journal.pgen.1004486
PMCID: PMC4102445

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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LIN-42, the Caenorhabditis elegans PERIOD homolog, negatively regulates microRNA transcription.PMID 25032706Read ↗

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The Period protein homolog LIN-42 negatively regulates microRNA biogenesis in C. elegans.Semantic proximity Read ↗

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<i>C. elegans</i> LIN-28 controls temporal cell-fate progression by regulating LIN-46 expression via the 5’UTR of <i>lin-46</i> mRNASemantic proximity Read ↗

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Misexpression of the Caenorhabditis elegans miRNA let-7 is sufficient to drive developmental programs.Semantic proximity Read ↗

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