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Article

Identification and rescue of a novel TUBB8 mutation that causes the first mitotic division defects and infertility.

Journal of assisted reproduction and genetics - 1 Nov 2020

Jia Yanping, Li Kunming, Zheng Caihong, Tang Yuanyuan, Bai Dandan, Yin Jiqing, Chi Fengli, Zhang Yalin, Li Yanhe, Tu Zhifen, Wang Yu, Pan Jiaping, Liang Shanshan, Guo Yi, Ruan Jingling, Kong Pengcheng, Wu Bi, Hu Ye, Wang Hong, Liu Wenqiang, Teng Xiaoming, Gao Shaorong

Abstract excerpt

PURPOSE: Tubulin beta eight class VIII (TUBB8) is essential for oogenesis, fertilization, and pre-implantation embryo development in human. Although TUBB8 mutations were recently discovered in meiosis-arrested oocytes of infertile females, there is no effective therapy for this gene mutation caused infertility. Our study aims to further reveal the infertility-causing gene mutations in the patient's family and to...

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Share to Cell Division
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32949002
DOI: 10.1007/s10815-020-01945-w
PMCID: PMC7642063

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Identification and rescue of a novel TUBB8 mutation that causes the first mitotic division defects and infertility.PMID 32949002Read ↗

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