Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FAM209 associates with DPY19L2, and is required for sperm acrosome biogenesis and fertility in mice

2 Sept 2021

Abstract excerpt

Infertility afflicts up to 15% of couples globally each year with men a contributing factor in 50% of these cases. Globozoospermia is a rare condition found in infertile men, which is characterized by defective acrosome biogenesis leading to the production of round-headed sperm. Here, we report that family with sequence similarity 209 (Fam209) is required for acrosome biogenesis in mouse sperm. FAM209 is a small...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Reproductive Biology and Fertility
Share to Sperm and Testicular Function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34471926
DOI: 10.1242/jcs.259206

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FAM209 associates with DPY19L2, and is required for sperm acrosome biogenesis and fertility in micePMID 34471926Read ↗

Novel DPY19L2 variants in globozoospermic patients and the overcoming this male infertilitySemantic proximity Read ↗

Proteomic Analysis of Dpy19l2‐Deficient Human Globozoospermia Reveals Multiple Molecular DefectsSemantic proximity Read ↗

Disruption of TEX38 impairs sperm morphogenesis and the migration of sperm into the oviductSemantic proximity Read ↗

Genetic analyses of a large cohort of infertile patients with globozoospermia, DPY19L2 still the main actor, GGN confirmed as a guest player.Semantic proximity Read ↗

LYPD4, mouse homolog of a human acrosome protein, is essential for sperm fertilizing ability and male fertility†Semantic proximity Read ↗

The full length BEND2 protein is dispensable for spermatogenesis but required for setting the ovarian reserve in miceSemantic proximity Read ↗

A Recurrent Deletion of DPY19L2 Causes Infertility in Man by Blocking Sperm Head Elongation and Acrosome FormationSemantic proximity Read ↗

FSIP2 plays a role in the acrosome development during spermiogenesisSemantic proximity Read ↗

Knockout of family with sequence similarity 170 member A (Fam170a) causes male subfertility, while Fam170b is dispensable in mice†Semantic proximity Read ↗

Leucine-rich Repeat Protein LRRC37A Acts as a Molecular Scaffold Coordinating IAM-PT-NE Complex Assembly and Sperm Head MorphogenesisSemantic proximity Read ↗

Exome sequencing reveals novel causes as well as new candidate genes for human globozoospermiaSemantic proximity Read ↗

Human globozoospermia‐related genes and their role in acrosome biogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.