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Article

FSIP2 plays a role in the acrosome development during spermiogenesis

2 Jun 2022

Abstract excerpt

Background Loss-of-function mutations in FSIP2 result in multiple morphological abnormalities of the flagella in humans and mice. Intriguingly, a recent study found that FSIP2 might regulate the expression of acrosomal proteins, indicating that Fsip2 might be involved in acrosome development in mice. However, whether FSIP2 also function in acrosome biogenesis in humans is largely unknown, and the underlying...

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PMID: 35654582
DOI: 10.1136/jmedgenet-2021-108406

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