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LYPD4, mouse homolog of a human acrosome protein, is essential for sperm fertilizing ability and male fertility†

10 Feb 2020

Abstract excerpt

Fertilization is one of the fundamental biological processes, but so far, we still do not have a full understanding of the underlying molecular mechanism. We have identified a human acrosome protein, LY6/PLAUR domain containing 4 (LYPD4), expressed specifically in human testes and sperm, and conserved within mammals. Mouse Lypd4, also specific to the testis and sperm, is essential for male fertility. LYPD4...

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PMID: 32040177
DOI: 10.1093/biolre/ioaa018

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