Article

The full length BEND2 protein is dispensable for spermatogenesis but required for setting the ovarian reserve in mice

2024-02-09

Abstract excerpt

Infertility affects up to 12% of couples globally, with genetic factors contributing to nearly half of the cases. Advances in genomic technologies have led to the discovery of genes like Bend2 , which plays a crucial role in gametogenesis. In the testis, Bend2 expresses two protein isoforms: full-length and a smaller one. Ablation of both proteins results in an arrested spermatogenesis. Because the Bend2 locus...

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Literature Corpus work: af0a5d40-aed1-57b1-8357-aee0bd97da63
DOI: 10.1101/2024.02.06.579114

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