Article
De novo transcriptomic subtyping of colorectal cancer liver metastases in the context of tumor heterogeneity.
Genome medicine - 1 Sept 2021
Moosavi Seyed H, Eide Peter W, Eilertsen Ina A, Brunsell Tuva H, Berg Kaja C G, Røsok Bård I, Brudvik Kristoffer W, Bjørnbeth Bjørn A, Guren Marianne G, Nesbakken Arild, Lothe Ragnhild A, Sveen Anita
Abstract excerpt
BACKGROUND: Gene expression-based subtyping has the potential to form a new paradigm for stratified treatment of colorectal cancer. However, current frameworks are based on the transcriptomic profiles of primary tumors, and metastatic heterogeneity is a challenge. Here we aimed to develop a de novo metastasis-oriented framework. METHODS: In total, 829 transcriptomic profiles from patients with colorectal cancer...
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