Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis.

doi:10.1038/s41467-018-04278-6

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Article

Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis.

Nature communications - 4 May 2018

Pitroda Sean P, Khodarev Nikolai N, Huang Lei, Uppal Abhineet, Wightman Sean C, Ganai Sabha, Joseph Nora, Pitt Jason, Brown Miguel, Forde Martin, Mangold Kathy, Xue Lai, Weber Christopher, Segal Jeremy P, Kadri Sabah, Stack Melinda E, Khan Sajid, Paty Philip, Kaul Karen, Andrade Jorge, White Kevin P, Talamonti Mark, Posner Mitchell C, Hellman Samuel, Weichselbaum Ralph R

Abstract excerpt

The oligometastasis hypothesis suggests a spectrum of metastatic virulence where some metastases are limited in extent and curable with focal therapies. A subset of patients with metastatic colorectal cancer achieves prolonged survival after resection of liver metastases consistent with oligometastasis. Here we define three robust subtypes of de novo colorectal liver metastasis through integrative molecular...

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PMID: 29728604
DOI: 10.1038/s41467-018-04278-6
PMCID: PMC5935683

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MYC
NOTCH1
VEGFA

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