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Article

Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia.

American journal of human genetics - 7 Oct 2021

Kachuri Linda, Jeon Soyoung, DeWan Andrew T, Metayer Catherine, Ma Xiaomei, Witte John S, Chiang Charleston W K, Wiemels Joseph L, de Smith Adam J

Abstract excerpt

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Despite overlap between genetic risk loci for ALL and hematologic traits, the etiological relevance of dysregulated blood-cell homeostasis remains unclear. We investigated this question in a genome-wide association study (GWAS) of childhood ALL (2,666 affected individuals, 60,272 control individuals) and a multi-trait GWAS of nine blood-cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34469753
DOI: 10.1016/j.ajhg.2021.08.004
PMCID: PMC8546033

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