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Characteristics of white blood cell count in acute lymphoblastic leukemia: A COST LEGEND phenotype-genotype study.

Pediatric blood & cancer - 1 Jun 2022

Helenius Marianne, Vaitkeviciene Goda, Abrahamsson Jonas, Jonsson Ólafur Gisli, Lund Bendik, Harila-Saari Arja, Vettenranta Kim, Mikkel Sirje, Stanulla Martin, Lopez-Lopez Elixabet, Waanders Esmé, Madsen Hans O, Marquart Hanne Vibeke, Modvig Signe, Gupta Ramneek, Schmiegelow Kjeld, Nielsen Rikke Linnemann

Abstract excerpt

BACKGROUND: White blood cell count (WBC) as a measure of extramedullary leukemic cell survival is a well-known prognostic factor in acute lymphoblastic leukemia (ALL), but its biology, including impact of host genome variants, is poorly understood. METHODS: We included patients treated with the Nordic Society of Paediatric Haematology and Oncology (NOPHO) ALL-2008 protocol (N = 2347, 72% were genotyped by...

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PMID: 35316565
DOI: 10.1002/pbc.29582

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