Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Innate Immunity Protein IFITM3 in Alzheimer's Disease

1 Sept 2021

Abstract excerpt

Several genes in innate immunity have been implicated in Alzheimer's disease (AD). However, the effect of innate immunity on amyloid β (Aβ) production, which makes amyloid plaques in AD brains, was previously not known. Recently, the antiviral protein interferon-induced transmembrane protein 3 (IFITM3) has been identified as a novel γ-secretase modulatory protein for Aβ production. In this review, the mechanisms...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Neuroinflammation and Neurodegeneration Mechanisms
Share to Tryptophan and brain disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34468206
DOI: 10.1089/dna.2021.0585

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Innate Immunity Protein IFITM3 in Alzheimer's DiseasePMID 34468206Read ↗

No Association between Single Nucleotide Polymorphisms (SNPs) of the Interferon-Induced Transmembrane Protein 3 (IFITM3) Gene and the Susceptibility of Alzheimer's Disease (AD).Semantic proximity Read ↗

Outside-in induction of the IFITM3 trafficking system by infections, including SARS-CoV-2, in the pathobiology of Alzheimer’s diseaseSemantic proximity Read ↗

FYN, SARS-CoV-2, and IFITM3 in the Neurobiology of Alzheimer’s Disease: A Regulatory Feedback Loop Governing Tau and Aβ PathologySemantic proximity Read ↗

Inhibition of IFITM3 in cerebrovascular endothelium alleviates Alzheimer's-related phenotypes.Semantic proximity Read ↗

IRF3 regulates neuroinflammatory responses and the expression of genes associated with Alzheimer’s diseaseSemantic proximity Read ↗

Type-I Interferon drives T-cell responses to Amyloid-beta in the central nervous systemSemantic proximity Read ↗

Modulation of Immune Responses to Herpes Simplex Virus Type 1 by IFNL3 and IRF7 Polymorphisms: A Study in Alzheimer's Disease.Semantic proximity Read ↗

Impaired Innate Immunity Mechanisms in the Brain of Alzheimer's Disease.Semantic proximity Read ↗

β-Amyloids and Immune Responses Associated with Alzheimer’s DiseaseSemantic proximity Read ↗

Immune receptor LAG3 regulates microglia function during Alzheimer’s diseaseSemantic proximity Read ↗

Identification of plasma inflammatory biomarkers for Alzheimer's disease reveals IFN-γ as a regulator of ACSL1-mediated microglia phenotype.Semantic proximity Read ↗

The FAM3 superfamily member ILEI ameliorates Alzheimer’s disease-like pathology by destabilizing the penultimate amyloid-β precursorSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.