Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of IFITM3 in cerebrovascular endothelium alleviates Alzheimer's-related phenotypes.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Feb 2025

Feng Yijia, Wang Shengya, Yang Danlu, Zheng Wu, Xia Huwei, Zhu Qinxin, Wang Zhipeng, Hu Bolang, Jiang Xinyi, Qin Xuemei, Ni Chenkang, Pan Wenhao, Zhao Yifan, Pan Sipei, Zhang Yun, Song Weihong

Abstract excerpt

INTRODUCTION: Interferon-induced transmembrane protein 3 (IFITM3) modulates γ-secretase in Alzheimer's Disease (AD). Although IFITM3 knockout reduces amyloid β protein (Aβ) production, its cell-specific effect on AD remains unclear. METHODS: Single nucleus RNA sequencing (snRNA-seq) was used to assess IFITM3 expression. Adeno-associated virus-BI30 (AAV-BI30) was injected to reduce IFITM3 expression in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Amyloid beta-Peptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amyloid Precursor Protein Secretases

Share to Aspartic Acid Endopeptidases

Share to Endothelial Cells

Share to Endothelium, Vascular

Share to Mice, Transgenic

Share to RNA-Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 39807629
DOI: 10.1002/alz.14543
PMCID: PMC11851164

Genes

IFITM3
APP
BACE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of IFITM3 in cerebrovascular endothelium alleviates Alzheimer's-related phenotypes.PMID 39807629Read ↗

FYN, SARS-CoV-2, and IFITM3 in the Neurobiology of Alzheimer’s Disease: A Regulatory Feedback Loop Governing Tau and Aβ PathologySemantic proximity Read ↗

Outside-in induction of the IFITM3 trafficking system by infections, including SARS-CoV-2, in the pathobiology of Alzheimer’s diseaseSemantic proximity Read ↗

Innate Immunity Protein IFITM3 in Alzheimer's DiseaseSemantic proximity Read ↗

Inflammatory reprogramming of human brain endothelial cells compromises blood–brain barrier integrity in Alzheimer’s diseaseSemantic proximity Read ↗

Single nuclear transcriptional signatures of dysfunctional brain vascular homeostasis in Alzheimer’s diseaseSemantic proximity Read ↗

No Association between Single Nucleotide Polymorphisms (SNPs) of the Interferon-Induced Transmembrane Protein 3 (IFITM3) Gene and the Susceptibility of Alzheimer's Disease (AD).Semantic proximity Read ↗

The FAM3 superfamily member ILEI ameliorates Alzheimer’s disease-like pathology by destabilizing the penultimate amyloid-β precursorSemantic proximity Read ↗

Non-viral vasculogenic reprogramming restores cognition and mitigates pathology in Alzheimer’s diseaseSemantic proximity Read ↗

Single-nucleus multiomics in brains from Hispanic individuals reveal<i>APOE-ε4</i>-driven disruption of focal adhesion signaling in the presence of cerebrovascular pathologySemantic proximity Read ↗

Deletion of <i>Abi3</i> / <i>Gngt2</i> influences age-progressive amyloid β and tau pathologies in distinctive waysSemantic proximity Read ↗

The Role of RIN3 Gene in Alzheimer’s Disease Pathogenesis: a Comprehensive ReviewSemantic proximity Read ↗

Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive waysSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.