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Article

Modulation of Immune Responses to Herpes Simplex Virus Type 1 by IFNL3 and IRF7 Polymorphisms: A Study in Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2017

Costa Andrea Saul, Agostini Simone, Guerini Franca Rosa, Mancuso Roberta, Zanzottera Milena, Ripamonti Enrico, Racca Vittorio, Nemni Raffaello, Clerici Mario

Abstract excerpt

Herpes simplex virus type 1 (HSV-1) has long been suspected to play a role in Alzheimer's disease (AD), the most common form of dementia. IFN-lambda (IFN-λ) is one of the key cytokine in innate antiviral defenses and, in particular, has an appreciable antiviral activity against HSV-1 infection. IFN-λ expression is regulated by the interaction between two different proteins: Mediator Complex 23 (MED23) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28984602
DOI: 10.3233/JAD-170520

Genes

IFNL3
MED23

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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