Article

SRSF2 transcriptional function maintains genome integrity during cell division

2024-07-08

Abstract excerpt

Recurrent mutations in serine / arginine-rich splicing factor 2 (SRSF2), particularly the proline-to-histidine substitution at position 95 (P95H), have been proposed to drive neoplastic diseases. SRSF2 plays pivotal roles in pre-mRNA processing and gene transcription. However, the precise impact of these diverse functions of SRSF2 on cancer cell behaviour remains unclear. Here, we show that deletion or homozy...

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Literature Corpus work: 1ca862a5-9ac8-5a28-80a4-c358a64b07dc
DOI: 10.1101/2024.07.08.602469

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