Article
Saccharomyces cerevisiae DNA repair pathways involved in repair of lesions induced by mixed ternary mononuclear Cu(II) complexes based on valproic acid with 1,10-phenanthroline or 2,2'- bipyridine ligands.
Mutation research. Genetic toxicology and environmental mutagenesis - 1 Jan 2000
Rodrigues Gabriel Berbigier, Dos Santos Silveira Priscila, Machado Miriana, Guecheva Temenouga Nikolova, Pich Claus Tröger, Roesch-Ely Mariana, Moura Sidnei, Dumas Françoise, de Oliveira Iuri Marques, Henriques João Antonio Pêgas
Abstract excerpt
The sodium valproate has been largely used as an anti-epilepsy drug and, recently, as a putative drug in cancer therapy. However, the treatment with sodium valproate has some adverse effects. In this sense, more effective and secure complexes than sodium valproate should be explored in searching for new active drugs. This study aims to evaluate the cytotoxicity of sodium valproate, mixed ternary mononuclear...
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