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Article

Homologous Recombination and Translesion DNA Synthesis Play Critical Roles on Tolerating DNA Damage Caused by Trace Levels of Hexavalent Chromium.

PloS one - 1 Jan 2016

Tian Xu, Patel Keyur, Ridpath John R, Chen Youjun, Zhou Yi-Hui, Neo Dayna, Clement Jean, Takata Minoru, Takeda Shunichi, Sale Julian, Wright Fred A, Swenberg James A, Nakamura Jun

Abstract excerpt

Contamination of potentially carcinogenic hexavalent chromium (Cr(VI)) in the drinking water is a major public health concern worldwide. However, little information is available regarding the biological effects of a nanomoler amount of Cr(VI). Here, we investigated the genotoxic effects of Cr(VI) at nanomoler levels and their repair pathways. We found that DNA damage response analyzed based on differential...

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Source

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Identifiers

PMID: 27907204
DOI: 10.1371/journal.pone.0167503
PMCID: PMC5132242

Genes

POLD3
REV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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