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Article

Multiform antimicrobial resistance from a metabolic mutation.

Science advances - 1 Aug 2021

Schrader Sarah M, Botella Hélène, Jansen Robert, Ehrt Sabine, Rhee Kyu, Nathan Carl, Vaubourgeix Julien

Abstract excerpt

A critical challenge for microbiology and medicine is how to cure infections by bacteria that survive antibiotic treatment by persistence or tolerance. Seeking mechanisms behind such high survival, we developed a forward-genetic method for efficient isolation of high-survival mutants in any culturable bacterial species. We found that perturbation of an essential biosynthetic pathway (arginine biosynthesis) in a...

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Identifiers

PMID: 34452915
DOI: 10.1126/sciadv.abh2037
PMCID: PMC8397267

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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