Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment.

eLife - 21 Feb 2017

Gomez James E, Kaufmann-Malaga Benjamin B, Wivagg Carl N, Kim Peter B, Silvis Melanie R, Renedo Nikolai, Ioerger Thomas R, Ahmad Rushdy, Livny Jonathan, Fishbein Skye, Sacchettini James C, Carr Steven A, Hung Deborah T

Abstract excerpt

Antibiotic resistance arising via chromosomal mutations is typically specific to a particular antibiotic or class of antibiotics. We have identified mutations in genes encoding ribosomal components in Mycobacterium smegmatis that confer resistance to several structurally and mechanistically unrelated classes of antibiotics and enhance survival following heat shock and membrane stress. These mutations affect...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Proteins
Share to Drug Resistance, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Profiling

Share to Gene Expression Regulation, Bacterial

Share to Mutation

Share to Mycobacterium smegmatis

Share to Proteome

Share to Ribosomes

Source

Open in PubMed Open full text

Identifiers

PMID: 28220755
DOI: 10.7554/eLife.20420
PMCID: PMC5319836

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment.PMID 28220755Read ↗

Alanine dependence of trans-translation contributes to riboregulation of mycobacterial antibiotic recalcitrance genesSemantic proximity Read ↗

Molecular Mechanisms Underlying Antimicrobial Resistance in Mycobacteria.Semantic proximity Read ↗

Mutation-based mechanisms of antibiotic resistance.Semantic proximity Read ↗

Heterogeneity in microbial antibiotic responses: genetic basis and within-host evolution.Semantic proximity Read ↗

A single upstream mutation of whiB7 underlies amikacin and clarithromycin resistance in Mycobacterium abscessus.Semantic proximity Read ↗

Multiform antimicrobial resistance from a metabolic mutation.Semantic proximity Read ↗

Ancestral antibiotic resistance in <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

Key resistance-associated mutations in multidrug-resistant tuberculosis: a genomic study from Shanghai, China, with a focus on aminoglycosides.Semantic proximity Read ↗

The DnaK Chaperone System Buffers the Fitness Cost of Antibiotic Resistance Mutations in Mycobacteria.Semantic proximity Read ↗

Tuberculosis treatment failure associated with evolution of antibiotic resilienceSemantic proximity Read ↗

A complex regulatory network controlling intrinsic multidrug resistance in Mycobacterium smegmatis.Semantic proximity Read ↗

Cell Wall Proteomics Reveal Phenotypic Adaption of Drug-Resistant Mycobacterium smegmatis to Subinhibitory Rifampicin ExposureSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.