Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Antibiotic resistance evolved via inactivation of a ribosomal RNA methylating enzyme.

Nucleic acids research - 14 Oct 2016

Stojković Vanja, Noda-Garcia Lianet, Tawfik Dan S, Fujimori Danica Galonić

Abstract excerpt

Modifications of the bacterial ribosome regulate the function of the ribosome and modulate its susceptibility to antibiotics. By modifying a highly conserved adenosine A2503 in 23S rRNA, methylating enzyme Cfr confers resistance to a range of ribosome-targeting antibiotics. The same adenosine is also methylated by RlmN, an enzyme widely distributed among bacteria. While RlmN modifies C2, Cfr modifies the C8...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Drug Resistance, Microbial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Methylation

Share to Methyltransferases

Share to Microbial Sensitivity Tests

Share to RNA, Ribosomal

Share to RNA, Transfer

Share to Substrate Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 27496281
DOI: 10.1093/nar/gkw699
PMCID: PMC5062987

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antibiotic resistance evolved via inactivation of a ribosomal RNA methylating enzyme.PMID 27496281Read ↗

Distinction between the Cfr methyltransferase conferring antibiotic resistance and the housekeeping RlmN methyltransferase.Semantic proximity Read ↗

Inactivation of the indigenous methyltransferase RlmN in Staphylococcus aureus increases linezolid resistance.Semantic proximity Read ↗

Ribosomal A site binding pattern differs between Arm methyltransferases from clinical pathogens and a natural producer of aminoglycosides.Semantic proximity Read ↗

Structural Basis for C <sup>8</sup> methylation of 23S ribosomal RNA by CfrSemantic proximity Read ↗

RlmQ: A Newly Discovered rRNA Modification Enzyme Bridging RNA Modification and Virulence Traits in <i>Staphylococcus aureus</i>Semantic proximity Read ↗

Mutations in RNA methylating enzymes in disease.Semantic proximity Read ↗

The Cfr rRNA Methyltransferase Confers Resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A AntibioticsSemantic proximity Read ↗

Two dynamic N-terminal regions are required for function in ribosomal RNA adenine dimethylase family members.Semantic proximity Read ↗

Expansion of the aminoglycoside-resistance 16S rRNA (m1A1408) methyltransferase family: Expression and functional characterization of four hypothetical enzymes of diverse bacterial originSemantic proximity Read ↗

Resistance to Linezolid Caused by Modifications at Its Binding Site on the RibosomeSemantic proximity Read ↗

Exogenously acquired 16S rRNA methyltransferases found in aminoglycoside-resistant pathogenic Gram-negative bacteria: An updateSemantic proximity Read ↗

Alanine dependence of trans-translation contributes to riboregulation of mycobacterial antibiotic recalcitrance genesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.