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Article

Role of transcriptional and posttranscriptional regulation of methionine adenosyltransferases in liver cancer progression

9 Feb 2012

Abstract excerpt

UNLABELLED: Down-regulation of the liver-specific MAT1A gene, encoding S-adenosylmethionine (SAM) synthesizing isozymes MATI/III, and up-regulation of widely expressed MAT2A, encoding MATII isozyme, known as MAT1A:MAT2A switch, occurs in hepatocellular carcinoma (HCC). Here we found Mat1A:Mat2A switch and low SAM levels, associated with CpG hypermethylation and histone H4 deacetylation of Mat1A promoter, and...

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PMID: 22318685
DOI: 10.1002/hep.25643

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