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Article

PTEN loss correlates with T cell exclusion across human cancers

19 Apr 2021

Abstract excerpt

BACKGROUND: Recent evidences had shown that loss in phosphatase and tensin homolog deleted on chromosome 10 (PTEN) was associated with immunotherapy resistance, which may be attributed to the non-T-cell-inflamed tumor microenvironment. The impact of PTEN loss on tumor microenvironment, especially regarding T cell infiltration across tumor types is not well understood. METHODS: Utilizing The Cancer Genome Atlas...

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PMID: 33874915
DOI: 10.1186/s12885-021-08114-x

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