Article

ATPase and protease domain movements in the bacterial AAA+ protease FtsH are driven by thermal fluctuations

2018-05-15

Abstract excerpt

AAA+ proteases are essential players in cellular pathways of protein degradation. Elucidating their conformational behavior is key for understanding their reaction mechanism and, importantly, for elaborating our understanding of mutation-induced protease deficiencies. Here, we study the structural dynamics of the Thermotoga maritima AAA+ hexameric ring metalloprotease FtsH ( Tm FtsH). Using a single-molecule För...

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Literature Corpus work: 44289f4a-61c8-5b98-bbff-0632790f1991
DOI: 10.1101/323055

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