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Article

ATPase and Protease Domain Movements in the Bacterial AAA+ Protease FtsH Are Driven by Thermal Fluctuations.

Journal of molecular biology - 26 Oct 2018

Ruer Martine, Krainer Georg, Gröger Philip, Schlierf Michael

Abstract excerpt

AAA+ proteases are essential players in cellular pathways of protein degradation. Elucidating their conformational behavior is key for understanding their reaction mechanism and, importantly, for elaborating our understanding of mutation-induced protease deficiencies. Here, we study the structural dynamics of the Thermotoga maritima AAA+ hexameric ring metalloprotease FtsH (TmFtsH). Using a single-molecule...

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Identifiers

PMID: 30044948
DOI: 10.1016/j.jmb.2018.07.023

Genes

SPG7

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