Article
Engineering protein assemblies with allosteric control via monomer fold-switching.
Nature communications - 13 Dec 2019
Campos Luis A, Sharma Rajendra, Alvira Sara, Ruiz Federico M, Ibarra-Molero Beatriz, Sadqi Mourad, Alfonso Carlos, Rivas Germán, Sanchez-Ruiz Jose M, Romero Garrido Antonio, Valpuesta José M, Muñoz Victor
Abstract excerpt
The macromolecular machines of life use allosteric control to self-assemble, dissociate and change shape in response to signals. Despite enormous interest, the design of nanoscale allosteric assemblies has proven tremendously challenging. Here we present a proof of concept of allosteric assembly in which an engineered fold switch on the protein monomer triggers or blocks assembly. Our design is based on the...
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