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Article

Zebrafish slc30a10 deficiency revealed a novel compensatory mechanism of Atp2c1 in maintaining manganese homeostasis.

PLoS genetics - 1 Jul 2017

Xia Zhidan, Wei Jiayu, Li Yingniang, Wang Jia, Li Wenwen, Wang Kai, Hong Xiaoli, Zhao Lu, Chen Caiyong, Min Junxia, Wang Fudi

Abstract excerpt

Recent studies found that mutations in the human SLC30A10 gene, which encodes a manganese (Mn) efflux transporter, are associated with hypermanganesemia with dystonia, polycythemia, and cirrhosis (HMDPC). However, the relationship between Mn metabolism and HMDPC is poorly understood, and no specific treatments are available for this disorder. Here, we generated two zebrafish slc30a10 mutant lines using the...

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Identifiers

PMID: 28692648
DOI: 10.1371/journal.pgen.1006892
PMCID: PMC5524415

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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