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Article

Manganese efflux transporter SLC30A10 missense polymorphism T95I associated with liver injury retains manganese efflux activity.

American journal of physiology. Gastrointestinal and liver physiology - 1 Jan 2023

Gurol Kerem C, Li Danyang, Broberg Karin, Mukhopadhyay Somshuvra

Abstract excerpt

The activity of the manganese (Mn) efflux transporter SLC30A10 in the liver and intestines is critical for Mn excretion and preventing Mn toxicity. Homozygous loss-of-function mutations in SLC30A10 are a well-established cause of hereditary Mn toxicity. But, the relationship between more common SLC30A10 polymorphisms, Mn homeostasis, and disease is only recently emerging. In 2021, the first coding SNP in SLC30A10...

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PMID: 36414535
DOI: 10.1152/ajpgi.00213.2022
PMCID: PMC9829465

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