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Article

Genetic Variants and Tumor Immune Microenvironment: Clues for Targeted Therapies in Inflammatory Breast Cancer (IBC).

International journal of molecular sciences - 19 Aug 2021

Gong Yulan, Nagarathinam Rajeswari, Arisi Maria F, Gerratana Lorenzo, Winn Jennifer S, Slifker Michael, Pei Jianming, Cai Kathy Q, Hasse Zachary, Obeid Elias, Noriega Julio, Sebastiano Christopher, Ross Eric, Alpaugh Katherine, Cristofanilli Massimo, Fernandez Sandra V

Abstract excerpt

To better understand the etiology of inflammatory breast cancer (IBC) and identify potential therapies, we studied genomic alterations in IBC patients. Targeted, next-generation sequencing (NGS) was performed on cell-free DNA (cfDNA) (n = 33) and paired DNA from tumor tissues (n = 29) from 32 IBC patients. We confirmed complementarity between cfDNA and tumor tissue genetic profiles. We found a high incidence of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34445631
DOI: 10.3390/ijms22168924
PMCID: PMC8396191

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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