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Article

Mutational landscape of inflammatory breast cancer.

Journal of translational medicine - 18 Apr 2024

Bertucci François, Lerebours Florence, Ceccarelli Michele, Guille Arnaud, Syed Najeeb, Finetti Pascal, Adélaïde José, Van Laere Steven, Goncalves Anthony, Viens Patrice, Birnbaum Daniel, Mamessier Emilie, Callens Céline, Bedognetti Davide

Abstract excerpt

BACKGROUND: Inflammatory breast cancer (IBC) is the most pro-metastatic form of BC. Better understanding of its enigmatic pathophysiology is crucial. We report here the largest whole-exome sequencing (WES) study of clinical IBC samples. METHODS: We retrospectively applied WES to 54 untreated IBC primary tumor samples and matched normal DNA. The comparator samples were 102 stage-matched non-IBC samples from TCGA....

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PMID: 38637846
DOI: 10.1186/s12967-024-05198-4
PMCID: PMC11025259

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