NOTCH and DNA repair pathways are more frequently targeted by genomic alterations in inflammatory than in non-inflammatory breast cancers.

doi:10.1002/1878-0261.12621

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Article

NOTCH and DNA repair pathways are more frequently targeted by genomic alterations in inflammatory than in non-inflammatory breast cancers.

Molecular oncology - 1 Mar 2020

Bertucci François, Rypens Charlotte, Finetti Pascal, Guille Arnaud, Adélaïde José, Monneur Audrey, Carbuccia Nadine, Garnier Séverine, Dirix Piet, Gonçalves Anthony, Vermeulen Peter, Debeb Bisrat G, Wang Xiaoping, Dirix Luc, Ueno Naoto T, Viens Patrice, Cristofanilli Massimo, Chaffanet Max, Birnbaum Daniel, Van Laere Steven

Abstract excerpt

Inflammatory breast cancer (IBC) is the most pro-metastatic form of breast cancer. Better understanding of its pathophysiology and identification of actionable genetic alterations (AGAs) are crucial to improve systemic treatment. We aimed to define the DNA profiles of IBC vs noninflammatory breast cancer (non-IBC) clinical samples in terms of copy number alterations (CNAs), mutations, and AGAs. We applied...

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PMID: 31854063
DOI: 10.1002/1878-0261.12621
PMCID: PMC7053236

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