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Inflammatory Breast Cancer: Clinical Implications of Genomic Alterations and Mutational Profiling

30 Sept 2020

Abstract excerpt

Inflammatory breast cancer (IBC) is a rare and aggressive type of breast cancer whose molecular basis is poorly understood. We performed a comprehensive molecular analysis of 24 IBC biopsies naïve of treatment, using a high-resolution microarray platform and targeted next-generation sequencing (105 cancer-related genes). The genes more frequently affected by gains were MYC (75%) and MDM4 (71%), while frequent...

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PMID: 33007869
DOI: 10.3390/cancers12102816

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