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Article

Comprehensive genomic profiling of inflammatory breast cancer cases reveals a high frequency of clinically relevant genomic alterations.

Breast cancer research and treatment - 1 Nov 2015

Ross Jeffrey S, Ali Siraj M, Wang Kai, Khaira Depinder, Palma Norma A, Chmielecki Juliann, Palmer Gary A, Morosini Deborah, Elvin Julia A, Fernandez Sandra V, Miller Vincent A, Stephens Philip J, Cristofanilli Massimo

Abstract excerpt

Inflammatory breast cancer (IBC) is a distinct clinicopathologic entity that carries a worse prognosis relative to non-IBC breast cancer even when matched for standard biomarkers (ER/PR/HER2). The objective of this study was to identify opportunities for benefit from targeted therapy, which are not currently identifiable in the standard workup for advanced breast cancer. Comprehensive genomic profiling on 53 IBC...

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Identifiers

PMID: 26458824
DOI: 10.1007/s10549-015-3592-z

Genes

ERBB2
MYC
BRCA2
FGFR1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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