Article
A functional role for Septin-2 in the maintenance of the axon initial segment and in human cognitive development.
Brain : a journal of neurology - 7 Jul 2026
Weiss Luisa, Pavez Macarena, Labudina Anastasia, Andriichuk Liliia, Jones Owen, Jones Amy, Barwick Deanna, Jenkins Zandra, Basak Indranil, Morgan Tim, Neuhann Teresa, Rankin Julia, Giltay Jacques, Agolini Emanuele, Novelli Antonio, Pizzuti Antonio, Koboldt Daniel C, Ramadesikan Swetha, Dublin-Ryan Leeran B, Hughes Stephanie, Di Donato Nataylia, Gimenez Greg, Namba Takashi, Gumy Laura F, Robertson Stephen P
Abstract excerpt
The establishment of neuronal polarity, whereby somatodendritic and axonal cellular compartments are defined, is a critical determinant for the development of neuronal networks and patterning during neurogenesis. The axon initial segment (AIS), a key structure in the establishment of this polarity, is formed through interactions between the microtubule and actin cytoskeleton, Ankyrin G, TRIM46 and multiple...
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