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Article

Disruption of APOL1-miR193a Axis Induces Disorganization of Podocyte Actin Cytoskeleton

5 Mar 2019

Abstract excerpt

Abstract APOL1-miR193a axis participates in the preservation of molecular phenotype of differentiated podocytes (DPDs). We examined the hypothesis that APOL1 (G0) preserves, but APOL1 risk alleles (G1 and G2) disrupt APOL1-miR193a axis in DPDs. DPDG0s displayed down-regulation of miR193a, but upregulation of nephrin expression. DPDG1s/G2s exhibited an increase in miR193a and down-regulation of the expression of...

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PMID: 30837512
DOI: 10.1038/s41598-019-39376-y

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