Article

ZEB1 shapes AML immunological niches suppressing CD8 T-cell activity while fostering Th17 cell expansion

2023-07-08

Abstract excerpt

<h4>ABSTRACT</h4> Acute myeloid leukemia (AML) development and progression is favored by immune suppression directly triggered by leukemia cells. ZEB1 is a key transcription factor in epithelial-to-mesenchymal transition which, we show here, is capable immune regulation in AML. Leukemic cells which had ZEB1 knocked down have reduced engraftment and extramedullary disease when transplanted into immune competent mi...

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Literature Corpus work: 7a12bf9d-1872-5fe8-8fd7-f53948223c6e
DOI: 10.1101/2023.07.08.548195

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