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Article

The Role of ZEB2 in Human CD8 T Lymphocytes: Clinical and Cellular Immune Profiling in Mowat-Wilson Syndrome.

International journal of molecular sciences - 18 May 2021

Frith Katie, Munier C Mee Ling, Hastings Lucy, Mowat David, Wilson Meredith, Seddiki Nabila, Macintosh Rebecca, Kelleher Anthony D, Gray Paul, Zaunders John James

Abstract excerpt

The Zeb2 gene encodes a transcription factor (ZEB2) that acts as an important immune mediator in mice, where it is expressed in early-activated effector CD8 T cells, and limits effector differentiation. Zeb2 homozygous knockout mice have deficits in CD8 T cells and NK cells. Mowat-Wilson syndrome (MWS) is a rare genetic disease resulting from heterozygous mutations in ZEB2 causing disease by haploinsufficiency....

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Identifiers

PMID: 34070208
DOI: 10.3390/ijms22105324
PMCID: PMC8158478

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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