Article

Year-long COVID-19 infection reveals within-host evolution of SARS-CoV-2 in a patient with B cell depletion

2021-10-05

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> B-cell depleting therapies may lead to protracted disease and prolonged viral shedding in individuals infected with SARS-CoV-2. Viral persistence in the setting of immunosuppression raises concern for viral evolution. <h4>Methods</h4> Amplification of sub-genomic transcripts for the E gene (sgE) was done on nasopharyngeal samples over the course of 355 days in a patient inf...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9f9d5bc4-1631-5149-b989-e455f7b0a2d4
DOI: 10.1101/2021.10.02.21264267

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Year-long COVID-19 infection reveals within-host evolution of SARS-CoV-2 in a patient with B cell depletionDOI 10.1101/2021.10.02.21264267Read

Yearlong COVID-19 Infection Reveals Within-Host Evolution of SARS-CoV-2 in a Patient With B-Cell DepletionSemantic proximity Read

Emergence of multiple SARS-CoV-2 mutations in an immunocompromised hostSemantic proximity Read

Intra-host evolution provides for continuous emergence of SARS-CoV-2 variantsSemantic proximity Read

SARS-CoV-2 evolution during prolonged infection in immunocompromised patientsSemantic proximity Read

Intra-Host Evolution Analyses in an Immunosuppressed Patient Supports SARS-CoV-2 Viral Reservoir Hypothesis.Semantic proximity Read

Intra-host viral populations of SARS-CoV-2 in immunosuppressed patients with hematologic cancersSemantic proximity Read

Intra-Host Evolution Provides for the Continuous Emergence of SARS-CoV-2 Variants.Semantic proximity Read

SARS-CoV-2 shedding and evolution in immunocompromised hosts during the Omicron period: a multicenter prospective analysisSemantic proximity Read

SARS-CoV-2 shedding, infectivity and evolution in an immunocompromised adult patientSemantic proximity Read

Persistent SARS-CoV-2 infection and increasing viral variants in children and young adults with impaired humoral immunitySemantic proximity Read

Extensive Intra-host evolution and T cell escape by SARS-CoV-2 in a 2.5-year persistent infection of an immunocompromised hostSemantic proximity Read

A Case Report Describing a Persistent SARS-CoV-2 Infection Outcomes and Mutations Associated with B-cell DeficiencySemantic proximity Read