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Article

Deciphering ion transport and ATPase coupling in the intersubunit tunnel of KdpFABC.

Nature communications - 24 Aug 2021

Silberberg Jakob M, Corey Robin A, Hielkema Lisa, Stock Charlott, Stansfeld Phillip J, Paulino Cristina, Hänelt Inga

Abstract excerpt

KdpFABC, a high-affinity K+ pump, combines the ion channel KdpA and the P-type ATPase KdpB to secure survival at K+ limitation. Here, we apply a combination of cryo-EM, biochemical assays, and MD simulations to illuminate the mechanisms underlying transport and the coupling to ATP hydrolysis. We show that ions are transported via an intersubunit tunnel through KdpA and KdpB. At the subunit interface, the tunnel...

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Identifiers

PMID: 34429416
DOI: 10.1038/s41467-021-25242-x
PMCID: PMC8385062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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