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Article

Salt-bridge dynamics control substrate-induced conformational change in the membrane transporter GlpT.

Journal of molecular biology - 9 May 2008

Law Christopher J, Almqvist Jonas, Bernstein Adam, Goetz Regina M, Huang Yafei, Soudant Celine, Laaksonen Aatto, Hovmöller Sven, Wang Da-Neng

Abstract excerpt

Active transport of substrates across cytoplasmic membranes is of great physiological, medical and pharmaceutical importance. The glycerol-3-phosphate (G3P) transporter (GlpT) of the E. coli inner membrane is a secondary active antiporter from the ubiquitous major facilitator superfamily that couples the import of G3P to the efflux of inorganic phosphate (P(i)) down its concentration gradient. Integrating...

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Identifiers

PMID: 18395745
DOI: 10.1016/j.jmb.2008.03.029
PMCID: PMC2426824

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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