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Article

Two-gate mechanism for phospholipid selection and transport by type IV P-type ATPases.

Proceedings of the National Academy of Sciences of the United States of America - 29 Jan 2013

Baldridge Ryan D, Graham Todd R

Abstract excerpt

Most P-type ATPases pump specific cations or heavy metals across a membrane to form ion gradients. However, the type IV P-type ATPases evolved the ability to transport specific phospholipid substrates rather than cations and function to establish plasma membrane asymmetry in eukaryotic cells. The mechanism for how a P-type ATPase, or any other transporter, can recognize and flip a phospholipid substrate is...

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Source

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Identifiers

PMID: 23302692
DOI: 10.1073/pnas.1216948110
PMCID: PMC3562821

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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