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Article

A universal coupling mechanism of respiratory complex I.

Nature - 1 Sept 2022

Kravchuk Vladyslav, Petrova Olga, Kampjut Domen, Wojciechowska-Bason Anna, Breese Zara, Sazanov Leonid

Abstract excerpt

Complex I is the first enzyme in the respiratory chain, which is responsible for energy production in mitochondria and bacteria1. Complex I couples the transfer of two electrons from NADH to quinone and the translocation of four protons across the membrane2, but the coupling mechanism remains contentious. Here we present cryo-electron microscopy structures of Escherichia coli complex I (EcCI) in different redox...

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Identifiers

PMID: 36104567
DOI: 10.1038/s41586-022-05199-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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