Article
Serine phosphorylation regulates the P-type potassium pump KdpFABC.
eLife - 21 Sept 2020
Sweet Marie E, Zhang Xihui, Erdjument-Bromage Hediye, Dubey Vikas, Khandelia Himanshu, Neubert Thomas A, Pedersen Bjørn P, Stokes David L
Abstract excerpt
KdpFABC is an ATP-dependent K+ pump that ensures bacterial survival in K+-deficient environments. Whereas transcriptional activation of kdpFABC expression is well studied, a mechanism for down-regulation when K+ levels are restored has not been described. Here, we show that KdpFABC is inhibited when cells return to a K+-rich environment. The mechanism of inhibition involves phosphorylation of Ser162 on KdpB,...
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