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Article

INFIMA leverages multi-omics model organism data to identify effector genes of human GWAS variants.

Genome biology - 23 Aug 2021

Dong Chenyang, Simonett Shane P, Shin Sunyoung, Stapleton Donnie S, Schueler Kathryn L, Churchill Gary A, Lu Leina, Liu Xiaoxiao, Jin Fulai, Li Yan, Attie Alan D, Keller Mark P, Keleş Sündüz

Abstract excerpt

Genome-wide association studies reveal many non-coding variants associated with complex traits. However, model organism studies largely remain as an untapped resource for unveiling the effector genes of non-coding variants. We develop INFIMA, Integrative Fine-Mapping, to pinpoint causal SNPs for diversity outbred (DO) mice eQTL by integrating founder mice multi-omics data including ATAC-seq, RNA-seq,...

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Identifiers

PMID: 34425882
DOI: 10.1186/s13059-021-02450-8
PMCID: PMC8381555

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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