Article

Quantifying Functional Conservation of Human and Mouse Regulatory Elements via FUNCODE

2024-11-03

Abstract excerpt

<h4>Summary</h4> Evolutionary conservation is crucial for understanding genome functions and lays the foundation for using animal models in studying human diseases. However, conventional conservation scores based on DNA sequence evolution do not capture the dynamic biochemical activities of DNA elements, termed functional conservation. Quantifying functional conservation has been limited by the availability of fu...

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Literature Corpus work: c7f4a44d-185d-54d7-bbf1-7fc73c91ddec
DOI: 10.1101/2024.10.31.620766

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