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Article

The In Situ Structure of Parkinson's Disease-Linked LRRK2.

Cell - 17 Sept 2020

Watanabe Reika, Buschauer Robert, Böhning Jan, Audagnotto Martina, Lasker Keren, Lu Tsan-Wen, Boassa Daniela, Taylor Susan, Villa Elizabeth

Abstract excerpt

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most frequent cause of familial Parkinson's disease. LRRK2 is a multi-domain protein containing a kinase and GTPase. Using correlative light and electron microscopy, in situ cryo-electron tomography, and subtomogram analysis, we reveal a 14-Å structure of LRRK2 bearing a pathogenic mutation that oligomerizes as a right-handed double helix around...

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Identifiers

PMID: 32783917
DOI: 10.1016/j.cell.2020.08.004
PMCID: PMC7869717

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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