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Antibody upstream sequence diversity and its biological implications revealed by repertoire sequencing.

Journal of genetics and genomics = Yi chuan xue bao - 20 Oct 2021

Zhu Yan, Yang Xiujia, Ma Cuiyu, Tang Haipei, Wang Qilong, Guan Junjie, Xie Wenxi, Chen Sen, Chen Yuan, Wang Minhui, Lan Chunhong, Sun Deqiang, Wei Lai, Sun Caijun, Yu Xueqing, Zhang Zhenhai

Abstract excerpt

The sequence upstream of the antibody variable region (antibody upstream sequence [AUS]) consists of a 5' untranslated region (5' UTR) and a preceding leader region. The sequence variations in AUS affect antibody engineering and PCR based antibody quantification and may also be implicated in mRNA transcription and translation. However, the diversity of AUSs remains elusive. Using 5' rapid amplification of cDNA...

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PMID: 34420911
DOI: 10.1016/j.jgg.2021.06.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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