Article
Antibody Upstream Sequence Diversity and Its Biological Implications Revealed by Repertoire Sequencing
2020-09-03
Abstract excerpt
The sequence upstream of antibody variable region (Antibody Upstream Sequence, or AUS) consists of 5’ untranslated region (5’ UTR) and two leader regions, L-PART1 and L-PART2. The sequence variations in AUS affect the efficiency of PCR amplification, mRNA translation, and subsequent PCR-based antibody quantification as well as antibody engineering. Despite their importance, the diversity of AUSs has long been negl...
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Identifiers and source
- Literature Corpus work
- cc8d91f1-daa0-59cc-8ca6-d18c7651fa9c
- DOI
- 10.1101/2020.09.02.280396