Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrative analyses of gene expression and chemosensitivity of patient-derived ovarian cancer spheroids link G6PD-driven redox metabolism to cisplatin chemoresistance

19 Aug 2021

Abstract excerpt

Patient-derived cells and xenografts retain the biological characteristics of clinical cancers and are instrumental in gaining a better understanding of the chemoresistance of cancer cells. Here, we have established a panel of patient-derived spheroids from clinical materials of ovarian cancer. Systematic evaluation using therapeutic agents indicated that sensitivity to platinum-based compounds significantly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Chemotherapy-induced organ toxicity mitigation
Share to Genomics, phytochemicals, and oxidative stress

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34419499
DOI: 10.1016/j.canlet.2021.08.018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrative analyses of gene expression and chemosensitivity of patient-derived ovarian cancer spheroids link G6PD-driven redox metabolism to cisplatin chemoresistancePMID 34419499Read ↗

Cell-intrinsic platinum response and associated genetic and gene expression signatures in ovarian cancer cell lines and isogenic modelsSemantic proximity Read ↗

Cisplatin Resistant Spheroids Model Clinically Relevant Survival Mechanisms in Ovarian TumorsSemantic proximity Read ↗

Disrupting G6PD-mediated Redox homeostasis enhances chemosensitivity in colorectal cancerSemantic proximity Read ↗

A panel of three oxidative stress-related genes predicts overall survival in ovarian cancer patients received platinum-based chemotherapySemantic proximity Read ↗

A highly annotated database of genes associated with platinum resistance in cancerSemantic proximity Read ↗

Platinum-Induced Mitochondrial OXPHOS Contributes to Cancer Stem Cell Enrichment in Ovarian CancerSemantic proximity Read ↗

GPT2 mediates metabolic alterations in platinum-resistant ovarian cancer cellsSemantic proximity Read ↗

New markers for human ovarian cancer that link platinum resistance to the cancer stem cell phenotype and define new therapeutic combinations and diagnostic toolsSemantic proximity Read ↗

Cell-intrinsic platinum response and associated genetic and gene expression signatures in ovarian cancerSemantic proximity Read ↗

Specific point mutations in key redox enzymes are associated with chemoresistance in epithelial ovarian cancer.Semantic proximity Read ↗

Resistance to glucose starvation as metabolic trait of platinum-resistant human epithelial ovarian cancer cells.Semantic proximity Read ↗

Steroid hormone biosynthesis pathway indicates platinum chemoresistance: Insights From Genomics and MetabolomicsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.