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Article

Specific point mutations in key redox enzymes are associated with chemoresistance in epithelial ovarian cancer.

Free radical biology & medicine - 1 Jan 2017

Fletcher Nicole M, Belotte Jimmy, Saed Mohammed G, Memaj Ira, Diamond Michael P, Morris Robert T, Saed Ghassan M

Abstract excerpt

Oxidative stress plays an important role in the pathophysiology of ovarian cancer. Resistance to chemotherapy presents a significant challenge for ovarian cancer treatment. Specific single nucleotide polymorphisms (SNPs) in key redox enzymes have been associated with ovarian cancer survival and progression. The objective of this study was to determine whether chemotherapy induces point mutations in key redox...

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Share to Carcinoma, Ovarian Epithelial
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cisplatin

Share to Drug Resistance, Neoplasm

Share to Neoplasms, Glandular and Epithelial

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Source

Identifiers

PMID: 27890641
DOI: 10.1016/j.freeradbiomed.2016.11.028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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