Article
Resistance to glucose starvation as metabolic trait of platinum-resistant human epithelial ovarian cancer cells.
Oncotarget - 24 Jan 2017
Pastò Anna, Pagotto Anna, Pilotto Giorgia, De Paoli Angela, De Salvo Gian Luca, Baldoni Alessandra, Nicoletto Maria Ornella, Ricci Francesca, Damia Giovanna, Bellio Chiara, Indraccolo Stefano, Amadori Alberto
Abstract excerpt
Deregulated glucose metabolism is observed in cancer but whether this metabolic trait influences response to or is modulated by cytotoxic drugs is unknown. We show here that tumor cells from epithelial ovarian cancer (EOC) patients can be categorized, according to their in vitro viability under glucose starvation, into glucose deprivation-sensitive (glucose-addicted, GA) and glucose deprivation-resistant (glucose...
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